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When Korra was being held captive by Tarrlok, Naga tracked her to the region exactly where she was and located her within the snow just after her escape. The animal proceeded to hold an fatigued Korra back again to Republic Metropolis on her again, where by the remainder of Group Avatar located them, guiding themselves on her howling.[2]

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For The only histidine substitutions, the N61H mutant is analogous in catalytic activity to your double mutant Whilst the Q59H mutant is diminished by fewer than an buy of magnitude relative to your wild style enzyme. For the substitutions at Asn-61, the replacement with the alanine is drastically much less disruptive in comparison to the alter to the histidine.

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-acetyl by-product. This result's according to the development or collapse in the tetrahedral intermediate as the rate restricting stage during the catalytic mechanism of NagA.

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